Associations
The primary goal of this study was to analyze urinary Na + , K + and the Na + :K + excretion ratio, for associations with changes in systolic blood pressure (SBP) in participants from the DASH–Sodium trial during the initial screening period in which participants were consuming their regular diet without dietary intervention. The secondary goals of this study were to investigate: (a) the impact of the salt sensitivity of blood pressure on these responses and (b) the impact of the DASH–Sodium dietary intervention, which lowers SBP and increases dietary K + intake, on these potential associations. Our analysis reports that in the DASH–Sodium study cohort: (1) a daily excretion of <1 g K + /day is associated with elevated SBP, (2) urinary K + excretion of >1 g/day does not correlate with a reduction in SBP and, (3) a reduction in the urinary Na + :K + excretion ratio is not associated with lower SBP irrespective of the salt sensitivity of blood pressure. Collectively our data support the recent DRI recommendation not to propose a DRI for K + and suggest that further evidence is required to support the establishment of a Na + /K + excretion ratio that would reduce SBP in the general population.
Logical details
Mean SBP in accordance with urinary salt so you’re able to potassium (Na + /K + ) excretion proportion in the course of testing in accordance with weight reduction input of Fat loss Approaches to Stop Blood pressure level (DASH) higher salt (HS) and you can lowest salt (LS) eating plan inside (a) salt painful and sensitive (letter = 71), (b) salt unwilling (n = 119) some one, beliefs shown once the indicate ± SD.
Significantly, we observed no association between the urinary Na + :K + ratio and SBP on the DASH HS or DASH LS dietary intervention in either SS (DASH HS R 2 = 0.04, DASH LS R 2 = 0.02) or SR (DASH HS R 2 = 0.04, DASH LS R 2 = 0.00002) participants (Fig. 5a, b). The DASH dietary intervention significantly increased the number of participants in both SS and SR groups with a urinary Na + :K + ratio of <1 on both the HS and LS diet. However, the urinary Na + :K + had no impact on SBP within dietary intake groups (Fig. 6a, b). Further, when expressed as a frequency distribution histogram the change in SBP from the DASH HS to LS dietary intervention exhibits a profound leftward shift in the SS group compared to SR group (Fig. 7a). In contrast, the frequency distribution histogram for change in the urinary Na + :K + ratio from the DASH HS to LS dietary intervention shows no difference in the Gaussian curve and distribution between SS and SR participants (Fig. 7b).
Next, several studies have recommended that the blood circulation pressure prevention evoked from the K + intake may be dependent on weight loss Na + intake [twenty eight, 29]. In our data of your own Dashboard-Sodium dataset i observed no relationship that have urinary K + excretion and you will SBP, during the patient evaluation visit or throughout Dash weight-loss input whenever Na + intake is actually changed, suggesting an independence of your own outcomes of Na + and you can K + for the SBP inside studies. The fresh 2019 DRI Statement figured there is diminished proof towards the the consequences regarding K + with the blood pressure levels and you can failed to present good DRI off K + . Our investigation contain the 2019 DRI Declaration and you may means that dieting K + supplements may not significantly lose blood pressure level in the standard society.
Conclusion
Stamler J, Flower Grams, Stamler R, Elliott P, Dyer A great, Marmot M. INTERSALT research results. Social health insurance and healthcare effects. Hypertension. 1989;–7.